The Joystiq Podcast crew hit their 49th episode this week, Chris Grant, Ludwig Kietzmann and Justin McElroy, are covering random games and lots of GTA4, as expected. The best part is their Philadelphian Vocal Pronunciation class. This link is their RSS feed, this one is the direct MP3, and this one is the iTunes subscription. In a previous episode they even answered a question from Y.T. about the Korean game industry.
The 1UP Show is covering Valkyrja of the Battlefield, Boom Blox, and Metal Gear Online. I really dug their coverage and am now more interested in all three games. This link is their RSS feed, and this one will subscribe you in iTunes.